Yokohama University of Pharmacy · Department of Kampo Pharmacy

Research keywordsSTAM1・Kami・●モデル動物を用いた認知症」に有効性を示す漢方薬の探索および機序解明・Fujiwara・●モデル動物を用いた発達障害に有効性を示す漢方薬の探索および機序解明

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• 1. STAM1-deficient mice exhibit an attention-deficit/hyperactivity disorder-like phenotype. Fujiwara H , Nakagawasai O, Suzuki S, Tajima H, Takahashi K, Onogi H, Sakuma W, Tan-No K, Murata K. Biochem Biophys Res Commun. 2026; 799:153264.2026
• 3. Kami-shoyo-san improves ASD-like behaviors caused by decreasing allopregnanolone biosynthesis in an SKF mouse model of autism. Guo QY, Ebihara K, Shimodaira T, Fujiwara H , Toume K, Dibwe DF, Awale S, Araki R, Yabe T, Matsumoto K. PLoS One. 2019;14:e0211266.2019
• 4. Orengedokuto and san'oshashinto improve memory deficits by inhibiting aging-dependent activation of glycogen synthase kinase-3β. Fujiwara H , Yoshida J, Dibwe DF, Awale S, Hoshino H, Kohama H, Arai H, Kudo Y, Matsumoto K. J Tradit Complement Med. 2018;9:328-335.2018
• 5. Endogenous acetylcholine regulates neuronal and astrocytic vascular endothelial growth factor expression levels via different acetylcholine receptor mechanisms. Kimura K, Matsumoto K, Ohtake H, Oka JI, Fujiwara H . Neurochem Int. 2018i118:42-51.2018

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