Yokohama University of Pharmacy · Department of Clinical Pharmacy · 准教授

Research keywords●トランスポーターのがん組織特異的な機能調節因子の同定とがん治療への応用・●B細胞リンパ腫における薬物耐性亢進メカニズムの解明・●がん選択性の高いDrug Delivery Systemの創出に関する研究・●苦味刺激による薬物の体内動態変動とそのメカニズムの探索・トランスポーター・がん組織・薬物耐性・Drug Delivery System・苦味刺激・薬物動態

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• 1. Yano K , Todokoro I, Kamioka H, Tomono T, Ogihara T. Functional Alterations of Multidrug Resistance-Associated Proteins 2 and 5, and Breast Cancer Resistance Protein upon Snail-Induced Epithelial-Mesenchymal Transition in HCC827 cells. Biol Pharm Bull. 2020 in press.2020
• 3. Arakawa H, Yamada H, Arai K, Kawanishi T, Nitta N, Shibata S, Matsumoto E, Yano K , Kato Y, Kumamoto T, Aoki I, Ogihara T. Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging. Int J Pharm. 2020;586:119575.2020
• 2. Mizoi K, Arakawa H, Yano K , Koyama S, Kojima H, Ogihara T. Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models. Biomedicines. 2020;8(10):374.2020
• 4. Kamioka H, Tomono T, Fujita A, Onozato R, Iijima M, Tsuchida S, Arai T, Fujita Y, Zhang X, Yano K , Ogihara T. Moesin-Mediated P-Glycoprotein Activation During Snail-Induced Epithelial-Mesenchymal Transition in Lung Cancer. J Pharm Sci. 2020;109(7):2302－2308.2020

• 音響・ナノ技術を統合した次世代型超音波がん治療法の開発
• 肺がんの上皮間葉転換に伴う薬剤耐性の獲得機構の解明と臨床の予測
• 排出系トランスポーター群の翻訳後共通因子を標的とするがん多剤耐性克服手法の構築
• 再発性リンパ腫の多剤耐性能および転移能の獲得機構の解明

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