Nihon University · Department of Pharmacy / Faculty of Pharmaceutical Sciences · 教授

Research keywords分子標的治療・抗がん剤／がん分子標的薬耐性・FLT3・急性骨髄性白血病

Research fieldsMolecular biology・医療薬学・Cell biology・Tumor biology・薬系衛生、生物化学

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• Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity2025 · Drug Metabolism and Disposition, 2025年11月, 査読有り, 通常論文
• Cyclin E1 overexpression sensitizes ovarian cancer cells to WEE1 and PLK1 inhibition.2025 · Oncogene, 2025年05月, 査読有り, 通常論文
• PLK1 or WEE1 inhibition targets homologous recombination repair proficiency in BRCA1/2 wild-type high-grade serous ovarian cancer2025 · Cell Death & Disease, 2025年, 査読有り, 通常論文
• Kaposi's sarcoma–associated herpesvirus replication and transcription activator protein activates2023 · gene promoter

• 急性骨髄性白血病におけるFLT3阻害薬重複耐性の分子機構と克服法の解明2021
• ABC輸送体活性・発現制御機構の解明と創薬基盤の構築2011
• Akt経路を介した細胞周期制御機構の解明2003

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