Tokyo University of Agriculture · Graduate School of Agriculture / Faculty of Agriculture

Research keywordsAMPK signaling・alternative splicing・metabolic regulation・hepatic steatosis・energy balance・obesity

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• 大豆乳酸菌発酵物はNrf2/SHP経路の活性化を介して血中および肝臓中脂質を減少させる
• The tuberous sclerosis complex model Eker (TSC2+/-) rat exhibits hyperglycemia and hyperketonemia due to decreased glycolysis in the liver
• Chrysin reduces the activity and protein level of mature forms of sterol regulatory element-binding proteins
• Metabolic abnormalities induced by mitochondrial dysfunction in skeletal muscle of the Eker (TSC2+/-) rat.

• AMPK-GSK3β複合体形成がグリコーゲン代謝へ及ぼす影響の解明
• AMPKがSRSF1を介して選択的スプライシングに及ぼす影響の解析
• AMPKの新規基質DDB1を介したユビキチン化修飾に及ぼす影響の解析

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