Tokyo University of Agriculture · Graduate School of Agriculture / Faculty of Agriculture · 助教

Research keywords再生医療・ゲノム編集・iPS細胞

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• Identification of a genetic locus responsible for the dominant white-spotting coat phenotype in mice spontaneously isolated from a Japanese wild-derived inbred strain.
• Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytes
• Fusion of histone variants to Cas9 suppresses non-homologous end joining.
• A novel missense mutation of Mip causes semi-dominant cataracts in the Nat mouse.

• 遺伝子治療を可能とするCRISPR/Cpf1による正確な欠失変異導入法の確立
• Cas12の連続的編集による高効率な欠失導入法の確立
• 細胞種により異なる倍数性の意義をiPS細胞モデルにより追究する
• 医療応用のための非ランダムなゲノム編集技術の開発

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