Ohu University · Faculty of Dentistry / Graduate School of Dentistry · 准教授

Research keywordsE2F1・p53 signaling・CDK7・cell migration・retinoblastoma protein・transcription regulation

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• Murine Embryonic Stem Cells Possess Distinct E2F Activity That Activates Tumor Suppressor Promoter Elements2026
• Ectopic expression of the CDK inhibitor p21Cip1 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter.
• Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1
• Distinct Regulation of the ARF and TAp73 Tumor Suppressor Genes by the Transcription Factor E2F1 Enables Discrimination of Cancer Cells from Normal Growing Cells

• 「匂いシグナル」で制御される口腔がん細胞の細胞融合誘導機構の解析
• 悪性がん細胞におけるミトコンドリアの品質管理機構の解明と増殖抑制法の開発
• 多核がん細胞の抗がん剤耐性を制御する分子機構の解析
• がん細胞におけるmRNAの四重鎖形成による転写因子E2F3の発現制御機構

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