Osaka Medical and Pharmaceutical University · Graduate School of Pharmaceutical Sciences / Department of Pharmacy / Faculty of Pharmaceutical Sciences · 教授

Research keywordsアルツハイマー病・アミロイドβ・γ-セクレターゼ・APP・TREM2・精神疾患・リバビリン・ボルナウイルス

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• γ-Secretase exosites as targets for substrate-selective lowering of Aβ generation.2026 · Structure (London, England : 1993) / 34 / 2
• Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset.2023 · Case reports in psychiatry / 2023
• APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain.2023 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society / 23 / 2
• Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.2022 · eLife / 11

• APP・セクレターゼ相互作用制御に基づく基質選択的アミロイドβ産生抑制法の開発2026
• 基質結合部位を標的とする副作用を抑えたアルツハイマー病の治療薬開発2023
• 認知症における超微形態特異的な重合分子モデルの開発2023
• 薬局を拠点とする包括的な認知症支援体制の構築とその効果検証2021

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