Osaka University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences

Research keywordsmedicinal chemistry・opioid receptor antagonists・naldemedine・CB1 CB2 agonists・antipruritic agents・antiarthritic agents・morphinan derivatives・natural product synthesis

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• Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects2019 · Bioorganic and Medicinal Chemistry Letters Vol. 29 No. 1 p. 73-77 2019年1月1日 研究論文（学術雑誌）
• Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent2012 · Bioorganic and Medicinal Chemistry Letters Vol. 22 No. 8 p. 2898-2901 2012年4月 研究論文（学術雑誌）
• CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: Reduction of CNS side effects by introducing polar functional groups2012 · Bioorganic and Medicinal Chemistry Letters Vol. 22 No. 8 p. 2894-2897 2012年4月 研究論文（学術雑誌）
• Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent2012 · Bioorganic and Medicinal Chemistry Letters Vol. 22 No. 8 p. 2803-2806 2012年4月 研究論文（学術雑誌）

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