Kobe Pharmaceutical University · Faculty of Pharmaceutical Sciences · 教授

Research keywords創薬化学・ケミカルバイオロジー・がん・蛍光プローブ・ストレス応答

Research fieldsイメージング・プローブ・薬系化学、創薬科学

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• Synthesis of various water-soluble C-60 derivatives and their superoxide-quenching activity
• [(Z)-2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(1-naphthyl)ethenylamino]formaldehyde oxime 1,4-dioxane hemisolvate
• A universal fluorogenic switch for Fe(II) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells
• Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment.

• 血管新生阻害療法のためのバイオプローブ分子設計とケミカルジェネティクス
• 転位反応を利用した含窒素複素環の構築
• Drug discovery and development on cancer microenviroment stress
• がん微小環境標的薬の開発と新規創薬標的の同定

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