Kobe Pharmaceutical University · Faculty of Pharmaceutical Sciences · 准教授

Research keywords変異抗体・分析化学・免疫測定法

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• Seeking high-priority mutations enabling successful antibody-breeding: systematic analysis of a mutant that gained over 100-fold enhanced affinity.
• Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein.
• Clonal array profiling of scFv-displaying phages for high-throughput discovery of affinity-matured antibody mutants.
• The VH framework region 1 as a target of efficient mutagenesis for generating a variety of affinity-matured scFv mutants.

• 次世代診断試薬創出プラットフォームの確立を目指す変異抗体選択法の抜本的改革
• オンサイト分析を指向した幻覚性キノコ成分の新規アッセイシステム構築
• 変異型シトクロムP450を分子認識素子として用いる低分子バイオマーカー測定法の開発
• 進化分子工学を基盤とする新規な「抗体様」臨床検査薬の創製と応用

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