Osaka University · Faculty of Medicine / Graduate School of Medical Sciences

Research keywordsliver senescence・NAFLD/NASH・liver carcinogenesis・autophagy in liver disease・alcohol-associated liver disease・hepatocyte apoptosis・p53 signaling・type III secretion system

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• White adipose tissue autophagy and adipose-liver crosstalk exacerbate non-alcoholic fatty liver disease in mice.
• Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis and tumorigenesis.
• Serum growth differentiation factor 15 is a novel biomarker with high predictive capability for liver cancer occurrence in patients with MASLD regardless of liver fibrosis.
• Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.

• 肝発癌過程におけるアポトーシスとオートファジーの統合解析と新規治療法の開発
• 脂肪組織-肝臓間クロストークに着目した肥満を伴う急性アルコール性肝炎の病態解明
• オートファジーの多面的作用に着目したアルコール性肝障害の病態改善機序の解明
• 非アルコール性脂肪肝炎の病態形成におけるω-6脂肪酸代謝異常の意義

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