Tokyo University of Science · Institute of Biomedical Sciences · 助教

Research fieldsHematology・Clinical internal medicine・Medicine, Dentistry, and Pharmacy・Clinical surgery・Orthopaedic surgery・Biological Sciences

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• Stage-specific roles of clonally expanded CD8+ T cells in regulating amyloid pathology in Alzheimer’s disease models2025 · Nature Communications
• The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models2024 · JOURNAL OF CLINICAL INVESTIGATION
• NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors.2024 · Journal for ImmunoTherapy of Cancer
• NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment.2024 · Cell Reports

• サイトカインシグナルの増強による抗腫瘍効果の増大と新たな抗腫瘍薬の開発
• NF-kB欠損マウスでの骨代謝のカップリング機構の破綻と破骨細胞前駆細胞の役割
• リンパ球とマクロファージの分化を支配する転写因子NF-kBの免疫制御機構の解明
• 放射線照射による骨髄内環境の損傷とマクロファージによる修復機構の解析

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