University of Miyazaki · Department of Medicine / Faculty of Medicine · 教授

Research keywords細胞死・小胞体ストレス・ASKファミリー・シグナル伝達・神経変性疾患

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• Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
• The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization
• ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney
• ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

• Derlinファミリーを介した新規小胞体品質管理機構の解明
• 口腔がん克服に向けた代謝ストレスシグナル制御機構の解明
• 遺伝子活性化基質を用いた硬組織再生に関する研究
• 病態脳における小胞体プロテオスタシス破綻によるコレステロール合成不全と脳萎縮

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