Hokkaido University · Faculty of Medicine / Graduate School of Medicine / Medical Research Institute · 講師

Research keywordsproteostasis・ubiquitin ligases・allergic inflammation・mucosal melanoma・ACE2 regulation・cell migration・heart failure・autoimmunity

Research fieldsGeneral medical chemistry・Medicine, Dentistry, and Pharmacy・Basic medicine・Environmental physiology (including Physical medicine and Nutritional physiology)・Biomedical structure and function and related fields・Biological Sciences

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• PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region.2025 · Journal of biomedical science, 32, 1, 88, 88, 2025年09月11日,
• Sez6l2 autoimmunity in a large cohort study.2023 · Journal of neurology, neurosurgery, and psychiatry, 94, 8, 667, 668, 2023年06月01日,
• TRIM27 expression is associated with poor prognosis in sinonasal mucosal melanoma.2023 · Rhinology, 2023年03月09日,
• FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.2023 · Proceedings of the National Academy of Sciences of the United States of America, 120, 24, e2218955120, 2023年06月13日,

• 直鎖状ユビキチン化による脂質代謝制御転写因子PPARガンマー活性化制御機構の解明
• ゲノムに局在するユビキチン様修飾分子Ufm1による生活習慣病防御機構の解明
• TRIMファミリータンパク質によるシグナル伝達制御
• 新規に開発した基質同定法を用いたがんドライバーユビキチンリガーゼの機能解析

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