Kyoto University · Center for iPS Cell Research and Application · 特定拠点助教

Research keywordssuper-resolution microscopy・human lung models (iPSCs・primary cells・organoids・precision-cut-lung-slices)・epithelial–mesenchymal–immune interactions・cytoskeletal dynamics・cell state plasticity and irreversibility

Research fieldsClinical internal medicine・Medicine, Dentistry, and Pharmacy・Respiratory organ internal medicine・Basic medicine・Experimental pathology・Biological Sciences

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• Planar cell polarity induces local microtubule bundling for coordinated ciliary beatingJournal of Cell Biology,
• In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.Stem cell reports,
• Transitional cell states sculpt tissue topology during lung regenerationCell Stem Cell,
• The Clinical Characteristics of Two Anti-OJ (Anti-Isoleucylt-RNA Synthetase) Autoantibody-Positive Interstitial Lung Disease Patients with Polymyositis/DermatomyositisINTERNAL MEDICINE,

• ヒトiPS細胞を用いた気道上皮細胞における細胞間の繊毛協調運動の確立
• 精密切断肺スライス培養を用いた肺線維症におけるtransitional stem cell stateの 線維化駆動メカニズムの解明
• 革新的癌発生モデルによる小細胞肺癌の治療抵抗性獲得機序の解明と新規治療標的の探索
• 新規治療標的探索を目的とした癌微小環境下での小細胞肺癌発生モデルの確立

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