Kitasato University · Faculty of Medical and Health Sciences · 教授

Research keywordshematopoietic stem cell gene therapy・induced pluripotent stem cells・stem cell culture systems・vector copy number・intestinal organoids・retroviral vectors・X-CGD

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• Protection of hematopoietic stem cells from stress-induced functional impairment by very low-dose interleukin-1 stimulation
• Kinetics and effect of integrin expression on human CD34(+) cells during murine leukemia virus-derived retroviral transduction with recombinant fibronectin for stem cell gene therapy.
• Gene transduction of tristetraprolin or its active domain reduces TNF-alpha production by Jurkat T cells.
• An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors.

• 究極の遺伝子治療法確立に必要なWASPの特性解明および移植造血幹細胞の制御法開発
• マルチカラーレトロウイルスベクターを用いた個体形成時の複数遺伝子競合的機能解析法
• ダウン症候群iPS細胞およびES細胞を用いた白血病発症機序解明と新規治療法の開発
• IKZFファミリー分子によるリンパ球分化制御とその破綻による病態に関する研究

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