Institute of Science Tokyo · Graduate School of Medical and Dental Sciences · 教授

Research keywordshepatocellular carcinoma・hepatic organoids・iPSC-derived models・FXR signaling・HBV integration・cancer immunotherapy

Research fieldsGastroenterology・General internal medicine and related fields・Clinical internal medicine・Medicine, Dentistry, and Pharmacy・Biological Sciences

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• Taro Shimizu, Masato Miyoshi, Sei Kakinuma, Jun Tsuchiya, Daisuke Yamane, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Kaho Yamada, Kotomi Shinozaki, Ayako Sato, Shun Kaneko, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto. Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids. Cell Rep. 2025.05; 44 (5): 115675. ( PubMed , DOI )2025
• Tomohiro Mochida, Masato Miyoshi, Sei Kakinuma, Taro Shimizu, Jun Tsuchiya, Keiya Watakabe, Kento Inada, Shun Kaneko, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto. Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoids. Stem Cell Reports. 2025.10; 20 (10): 102642. ( PubMed , DOI )2025
• Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto. Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model. Cell Mol Gastroenterol Hepatol. 2024.10; 19 (2): 101422. ( PubMed , DOI )2024
• Watakabe K, Miyoshi M, Kakinuma S, Sato A, Tsuchiya J, Shimizu T, Mochida T, Inada K, Kaneko S, Kawai-Kitahata F, Murakawa M, Nitta S, Nakagawa M, Oshima S, Watanabe M, Ma A, Asahina Y, Okamoto R. A20 in hepatic stellate cells suppresses chronic hepatitis by inhibiting DCLK1-JNK pathway-dependent chemokines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024.07; 38 (13): e23757. ( PubMed , DOI )2024

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