Aoyama Gakuin University · Faculty of Science and Engineering · 教授

Research keywords生物有機化学・Bioorganic Chemistry・Organic Synthesis・Photo Chemistry・光化学・放射線化学・有機合成化学

Research fieldsChemistry related to living body・Chemical biology・Nano/Micro science・Nanomaterials/Nanobioscience・内科・Chemistry・Medicine・Medicine, Dentistry, and Pharmacy

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• Probing DNA mismatched and bulged structures by using19F NMR spectroscopy and oligodeoxynucleotides with an19F-labeled nucleobase
• Stepwise regulation of hole transport in DNA by control of triplex formation
• One-electron reduction characteristics of N(3)-substituted 5-fluorodeoxyuridines synthesized as radiation-activated prodrugs
• Reductive activation of 5-fluorodeoxyuridine prodrug possessing azide methyl group by hypoxic X-irradiation

• 光照射ならびに放射線照射により活性を発現するプロドラッグの開発
• 核酸の化学修飾による会合体形成と核酸医薬品への応用
• 会合体形成による核酸医薬の高機能化と評価
• 腫瘍内酸素濃度の定量計測に基づくがん放射線療法の最適照射条件の探索

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