Tokyo University of Pharmacy and Life Sciences · School of Life Sciences · 教授

Research keywordsepigenetic drug discovery・CBX2 inhibitors・G9a inhibitors・HDAC1・HDAC2・SIRT2 inhibitors・DNA methyltransferase inhibition・glutaminyl cyclase・Alzheimer disease therapeutics

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• Identification of substituted acetanilide compounds as small molecule CBX2 inhibitors via in silico screening.2025 · Biochemical and biophysical research communications
• HDAC1 and HDAC2 are bidirectional enzymes that catalyze histone sorbylation to induce epigenetic alterations2025 · Springer Science and Business Media LLC
• Identification of benzimidazole-6-carboxamide based inhibitors of secretory glutaminyl cyclase for the treatment of Alzheimer's disease2025 · International Journal of Biological Macromolecules
• Discovery of potent substrate-type lysine methyltransferase G9a inhibitors for the treatment of sickle cell disease.2025 · European journal of medicinal chemistry

• リシンアセチル化による後成遺伝情報の発現と継承の仕組みを理解する2024 · 科学研究費助成事業
• リジン脂質修飾による新規脂質代謝調節機構の解明とその制御2024 · 科学研究費助成事業
• 代謝活性化を介した民生品のタンパク質付加体形成によるエピジェネティクス変化2023 · 科学研究費助成事業
• 代謝活性化を介した民生品のタンパク質付加体形成によるエピジェネティクス変化2023 · 科学研究費助成事業

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