Tohoku University · International Research Institute of Disaster Science · 教授

Research keywordsHIV-1・多剤耐性HIV・核酸系逆転写酵素阻害薬・EFdA・HIV融合阻害ペプチド・gp41・抗ウイルス薬評価・インテグラーゼ阻害薬・抗ヘルペスウイルス薬・薬剤耐性変異

Research fieldsApplied pharmacology・Infectious disease medicine・内科・内科学一般・Clinical internal medicine・Medicine・Medicine, Dentistry, and Pharmacy・Boundary medicine

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• Structural basis for the interaction of CCR5 with a small molecule, functionally selective CCRS agonistYuji Saita, Eiichi Kodama, Masaya Orita, Mitsuhiro Kondo, Takahiro Miyazaki, Kenji Sudo, Keiko Kajiwara, Masao Matsuoka, Yasuaki Shimizu
• Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cellsA Otaka, M Nakamura, D Nameki, E Kodama, S Uchiyama, S Nakamura, H Nakano, H Tamamura, Y Kobayashi, M Matsuoka, N Fujii
• Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virusShinya Oishi, Yasuyo Kodera, Hiroki Nishikawa, Hirotaka Kamitani, Tsuyoshi Watabe, Hiroaki Ohno, Tadafumi Tochikura, Kazuki Shimane, Eiichi Kodama, Masao Matsuoka, Fuminori Mizukoshi, Hajime Tsujimoto, Nobutaka Fujii
• Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

• Ｔｒａｎｓｌｏｃａｔｉｏｎ ｄｅｆｅｃｔｉｖｅ逆転写酵素阻害剤に対する耐性機序芦野 有悟, 児玉 栄一
• 本邦で見出された新規多剤耐性変異N348IのHIV逆転写酵素に及ぼす影響に関する研究児玉 栄一
• ストレス応答生合成と化学修飾を融合した多様性天然物による難治性疾患治療薬の開発児玉 栄一, 林 宏典, 浅井 禎吾, 菊地 晴久
• HIV吸着・膜融合過程を標的とする多剤耐性克服型HIV化学療法剤の開発

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