Kyorin University · Unclassified · 教授

Research keywordsがん・融合遺伝子・白血病・ゲノム・リンパ腫

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• 1. Okuda T, Taki T, Nishida K, Chinen Y, Nagoshi H, Sakakura C, Taniwaki M. Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26. Oncol Lett 13: 215-221, 20172017 · 主要研究業績
• 2. Nagoshi H, Taki T, Chinen Y, Tatekawa S, Tsukamoto T, Maegawa S, Yamamoto-Sugitani M, Tsutsumi Y, Kobayashi T, Matsumoto Y, Horiike S, Okuno Y, Fujiwara S, Hata H, Kuroda J, Taniwaki M. Transcriptional dysregulation of the deleted in colorectal carcinoma gene in multiple myeloma and monoclonal gammopathy of undetermined significance. Genes Chromosomes Cancer 54: 788-795, 20152015 · 主要研究業績
• 4. Yokokawa Y, Taki T, Akiyama M, Kobayashi S, Nagoshi H, Chinen Y, Morimoto A, Ida H, Taniwaki M. Unique clonal relationship between T-cell acute lymphoblastic leukemia and subsequent Langerhans cell histiocytosis with TCR rearrangement and NOTCH1 mutation. Genes Chromosomes Cancer 54: 409-417, 20152015 · 主要研究業績
• 6. Kobayashi S, Taki T, Nagoshi H, Chinen Y, Yokokawa Y, Kanegane H, Matsumoto Y, Kuroda J, Horiike S, Nishida K, Taniwaki M. Identification of novel fusion genes with 28S ribosomal DNA in hematologic malignancies. Int J Oncol 44: 1193-1198, 20142014 · 主要研究業績

• MLL遺伝子の融合遺伝子のRDA法とマイクロアレイを用いた標的遺伝子の単離と解析
• MLL-AF4,MLL-AF5q31による急性リンパ性白血病の発症機構の解明
• 転座関運キメラ遺伝子と細胞増殖関運因子の異常による転座型白血病の発症機構の解析
• 腫瘍発生における多様なゲノム構造異常およびキメラ遺伝子形成の分子機構の解明

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