Institute of Science Tokyo · Institute for Advanced Studies · 教授

Research keywords細胞遊走・イノシトールリン脂質・炎症・がん転移・シグナル伝達

Research fieldsBiological pharmacy・Cell biology・Clinical internal medicine・General medical chemistry・Medicine, Dentistry, and Pharmacy・Basic medicine・基礎生物科学・Clinical surgery

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• Rina Kawaguchi, Tsunehiro Miyakoshi, Akira Yoshimoto, Shoichi Hosoya, Yuki Kugii, Takehiko Sasaki, Nobuharu Suzuki, Ryunosuke Ohkawa. Homocysteine thiolactone affects paraoxonase 1 activity via altered paraoxonase 1 distribution on high-density lipoprotein particles. Biosci Rep. 2026.01; ( PubMed , DOI )2026
• Kofuji, S; Wolfe, K; Sumita, K; Kageyama, S; Yoshino, H; Hirota, Y; Ogawa-Iio, A; Kanoh, H; Sasaki, M; Kofuji, K; Davis, MI; Pragani, R; Shen, M; Boxer, MB; Nakatsu, F; Nigorikawa, K; Sasaki, T; Takeuchi, K; Senda, T; Kim, SM; Edinger, AL; Simeonov, A; Sasaki, AT. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2024.07; 718 149981. ( PubMed , DOI )2024
• Oikawa, T; Hasegawa, J; Handa, H; Ohnishi, N; Onodera, Y; Hashimoto, A; Sasaki, J; Sasaki, T; Ueda, K; Sabe, H. p53 ensures the normal behavior and modi fi cation of G1/S-speci fi c histone H3.1 in the nucleus LIFE SCIENCE ALLIANCE. 2024.09; 7 (9): ( PubMed , DOI )2024
• Chessa TAM, Jung P, Anwar A, Suire S, Anderson KE, Barneda D, Kielkowska A, Sadiq BA, Lai IW, Felisbino S, Turnham DJ, Pearson HB, Phillips WA, Sasaki J, Sasaki T, Oxley D, Spensberger D, Segonds-Pichon A, Wilson M, Walker S, Okkenhaug H, Cosulich S, Hawkins PT, Stephens LR. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Molecular cell. 2023.08; 83 (16): 2991-3009.e13. ( PubMed , DOI )2023

• イノシトールリン脂質を作用点とした感染応答の制御
• 高病原性インフルエンザウイルスによる呼吸不全における細胞膜リン脂質の役割
• 脂質脱リン酸化酵素阻害によるリソソーム機能賦活・長寿モデルマウスの開発
• 顕微鏡的多発血管炎モデルマウスの開発と応用

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