Tokyo Metropolitan University · Graduate School of Science / Faculty of Science · 准教授

Research keywordsRNA mass spectrometry・ribosome structure・RNA modification・pseudouridine analysis・stable isotope labeling・RNA analytics

Research fieldsGenome science・Complex systems・Genome biology・Biomedical engineering・Analytical chemistry・Chemistry・Medicine, Dentistry, and Pharmacy・Clinical surgery

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• 1．Liquid Chromatography-mass spectrometrybased qualitative profiling of mRNA therapeutic reagents using stable isotopelabeled standards followed by the automatic quantitation software AriadneNakayama H, Nobe Y, Koike M, Taoka M*. Anal Chem95(2), 1366-1375 (2023).2023 · 研究業績 · _other
• 2．PDGF-B secreted from skeletal muscle enhances myoblast proliferation and myotube maturation via activation of the PDGFR signaling cascadeHamaguchi H, Dohi k, Sakai T, Taoka M, Isobe T, Tsubasa MS, Deguchi S, Furuichi Y, Fujii NL, Manabe Y*. Biochem Biophys Res Commun639 (8), 169-175 (2023).2023 · 研究業績 · _other
• 4．Cryo-EM structure and rRNA modification sites of a plant ribosomeCottilli P, Itoh Y, Nobe Y, Petrov AS, Lison P, Taoka M*, Amunts A*. Plant Commun3(5), 100342 (2022).2022 · 研究業績 · _other
• 3．Ubiquitination-coupled liquid phase separation regulates the accumulation of the TRIM family of ubiquitin ligases into cytoplasmic bodiesTozawa T, Matsunaga K, Izumi T, Shigehisa N, Uekita T, Taoka M, Ichimura T*. PLoS One17(8), e0272700 (2022).2022 · 研究業績 · _other

• 組織損傷時に放出される細胞内タンパク質群の“細胞外機能”と単球表面への結合機序
• シュードウリジン：新しいガンマーカーの探索
• 核内相分離構造体の骨格となるRNAと生理機能の解明
• RNAの転写後修飾の網羅的な定量法の開発

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