Tokyo University of Science · Faculty of Pharmaceutical Sciences · 教授

Research keywords放射線生物学・免疫学・ATP受容体・P2X7・細胞死

Research fieldsQuantum beam science・Drug development chemistry・Medicine, Dentistry, and Pharmacy・Boundary medicine・Boundary agriculture・Applied molecular and cellular biology・Applied pharmacology・Risk sciences of radiation/Chemicals

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• Radiosensitizing Effect of P2X7 Receptor Antagonist on Melanoma in Vitro and in Vivo
• Induction of extracellular ATP mediates increase of intracellular thioredoxin in RAW264.7 cells exposed to low-dose gamma-rays.
• The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1β under acidic extracellular pH in LPS-primed microglial cells.
• Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects

• ATP開口放出の生理的役割の解明
• Study of physiological function of P2 receptors in immune cells
• 神経調節因子の自然免疫系における役割の解明
• 非ＤＮＡに対する放射線損傷に伴う生物影響の検討

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