Tokyo University of Science · Faculty of Pharmaceutical Sciences · 教授

Research keywordsウイルス、分子標的学、がん

Research fieldsBiological pharmacy・Molecular biology・Drug development chemistry・Medicine, Dentistry, and Pharmacy・基礎生物科学・Functional biochemistry・Biology・Biological science

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• Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression: differential effects of Bcl-2 and Bcl-x(L) on Bax-induced caspase activation and apoptosis
• Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.
• SARS-CoV-2 Spike Protein Mutation at Cysteine-488 Impairs Its Golgi Localization and Intracellular S1/S2 Processing
• Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses

• Myc依存型アポトーシスを利用した癌の分子標的治療法の開発
• Myc依存的アポトーシスを制御する癌の分子標的治療法の開発
• 癌原遺伝子産物c-Mycを分子標的としたアポトーシス誘導型がん治療法の開発
• 細胞周期制御における新規蛋白質リン酸化酵素Nek9の機能解析

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