Tokyo University of Agriculture and Technology · Graduate School of Engineering / Institute of Engineering · 教授

Research keywords抗体工学・タンパク質工学・治療抗体・バイオセンサー

Research fieldsProcess engineering・Laboratory animal science・Engineering・Biofunction/Bioprocess・Process/Chemical engineering・Medicine, Dentistry, and Pharmacy・General surgery・Clinical surgery

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• Highly Enhanced Cytotoxicity of a Dimeric Bispecific Diabody, the hEx3 Tetrabody
• Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting, of lymphocytes to tumor cells
• Development of glycated peptide enzyme sensor based flow injection analysis system for haemoglobin A1c monitoring using quasi-direct electron transfer type engineered fructosyl peptide oxidase.
• Enhancement of Cellulolytic Enzyme Activity by Clustering Cellulose Binding Domains on Nanoscaffolds

• 次世代バイオ医薬品を目指した低分子二重特異性抗体の基盤技術開発
• 低分子二重特異性抗体の機能的な構造の解明に向けた既存抗ペプチド抗体の結晶化抗体化
• 癌免疫治療薬への応用を目指す組換え型二重特異性抗体の蛋白質工学
• 機能性タンパク質ナノブロック複合体創製の基盤的プロセス技術開発と応用展開

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