Institute of Science Tokyo · International Research Institute for Medical-Engineering Collaboration · 教授

Research keywords核酸医薬・ヘテロ二本鎖オリゴヌクレオチド・デュシェンヌ型筋ジストロフィー・多発性硬化症・視神経脊髄炎・進行性核上性麻痺・末梢神経病理・機械学習神経形態計測・アレキサンダー病・αシヌクレイン病理

Research fieldsDrug development chemistry・Laboratory animal science・Neurology・Neurochemistry/Neuropharmacology・Complex systems・Biomedical engineering・内科・Clinical internal medicine

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• Sanjo N, Suzuki M, Yoshihama R, Toyoshima Y, Mizuta I, Fujita N, Usuda H, Uchiyama Y, Yasuda R, Yoshida T, Yamada M, Yokota T. Substitution of Glu to Lys at Codon 332 on the GFAP Gene Alone Is Causative for Adult-onset Alexander Disease. Internal medicine (Tokyo, Japan). 2024.01; 63 (2): 309-313. ( PubMed , DOI )2024
• Hasegawa J, Nagata T, Ihara K, Tanihata J, Ebihara S, Yoshida-Tanaka K, Yanagidaira M, Ohara M, Sasaki A, Nakayama M, Yamamoto S, Ishii T, Iwata-Hara R, Naito M, Miyata K, Sakaue F, Yokota T. Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nature communications. 2024.09; 15 (1): 7530. ( PubMed , DOI )2024
• Matsubayashi T, Yoshioka K, Lei Mon SS, Katsuyama M, Jia C, Yamaguchi T, Hara RI, Nagata T, Nakagawa O, Obika S, Yokota T. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine. Molecular therapy. Nucleic acids. 2024.06; 35 (2): 102161. ( PubMed , DOI )2024
• Hirata K, Matsuoka K, Tagai K, Endo H, Tatebe H, Ono M, Kokubo N, Kataoka Y, Oyama A, Shinotoh H, Takahata K, Obata T, Dehghani M, Near J, Kawamura K, Zhang MR, Shimada H, Shimizu H, Kakita A, Yokota T, Tokuda T, Higuchi M, Takado Y. In Vivo Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy. Annals of neurology. 2024.08; 96 (2): 247-261. ( PubMed , DOI )2024

• リガンド分子非依存性核酸医薬の新規開発
• DRPLAに対する核酸医薬を用いた遺伝子治療確立のための国際共同研究
• ＲＮＡ干渉を用いた遺伝子治療
• ビタミンE転移蛋白遺伝子に点変異を有する脊髄小脳変性症網膜色素変性症の発症機序

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