Ritsumeikan University · Faculty of Life Sciences / Graduate School of Life Sciences · 教授

Research keywordspluripotent stem cells・cardiac differentiation・Wnt signaling・embryonic heart development・enhancer analysis

Research fieldsMedical genome science・Genome science・Biomedical engineering and related fields・Clinical internal medicine・Medicine, Dentistry, and Pharmacy・Circulatory organs internal medicine・Biological Sciences・Biological Sciences

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• Hey2 enhancer activity defines unipotent progenitor cells for left ventricular cardiomyocytes in the juxta-cardiac field during early heart formation. │ Proc Natl Acad Sci U S A. │ 120 (37),e23076581202023
• c-Myc/microRNA-17-92 axis phase-dependently regulates PTEN and p21 expression via ceRNA during reprogramming to mouse pluripotent stem cells. │ Biomedicines. │ 11 (6),17372023
• Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells. │ Inflamm Regen. │ 43 (1),112023
• Computational and experimental analyses for pathogenicity prediction of ACVRL1 missense variants in hereditary hemorrhagic telangiectasia. │ J Clin Med. │ 12,50022023

• ダイレクトリプログラミングによる心臓ペースメーカ細胞誘導法の確立 │ 挑戦的研究（萌芽）2021
• RNA結合タンパク質Quakingによる網膜初期発生の分子機構の解明 │ 基盤研究(C) (キーワード：網膜, 3次元網膜分化法, Quaking)2020
• 時空間視覚情報処理を実現する網膜ダイナミクスの機能構築理解と数理モデル構築 │ 基盤研究(A)2019
• 初期化と細胞分化に関わるストレス応答の生体イメージングとその再生医学への応用 │ 挑戦的萌芽研究2017

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