Gunma University of Health and Welfare · 医療技術学部 · 教授

Research keywords分子生物学・脂肪酸・グルコース・代謝・心臓病学・循環器内科学・急性腎障害・血管生物学・心不全・腎不全

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• Kawakami R, Matsui H, Matsui M, Iso T, Yokoyama T, Ishii H, Kurabayashi M. Empagliflozin induces the transcriptional program for nutrient homeostasis in skeletal muscle in normal mice. Sci Rep. 2023 Oct 21;13(1):18025. doi:10.1038/s41598-023-45390-y. PMID: 37865720; PMCID: PMC10590450.2023
• Nagata R, Obokata M, Matsui M, Matsui H, Seki Y, Igarashi T, Sunaga H, Kawakami R, Harada T, Kagami K, Saeki H, Shirabe K, Iso T, Ishii H. Pathophysiologic Contributions of Visceral Adiposity to Left Ventricular Diastolic Dysfunction. J Cardiovasc Dev Dis. 2023 Jun 5;10(6):247. doi:10.3390/jcdd10060247. PMID: 37367412.2023
• Kawakami R, Sunaga H, Iso T, Kaneko R, Koitabashi N, Obokata M, Harada T, Matsui H, Yokoyama T, Kurabayashi M. Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart. Sci Rep. 2022 May 5;12(1):7338. doi: 10.1038/s41598-022-10993-4. PMID: 35513524.2022
• Kawakami R, Hanaoka H, Kanai A, Obinata H, Nakano D, Ikeuchi H, Matsui M, Matsuzaki T, Tanaka R, Sunaga H, Goto S, Matsui H, Koitabashi N, Saegusa K, Yokoyama T, Hiromura K, Nishiyama A, Saito A, Yanagita M, Ishii H, Kurabayashi M, Iso T. Robust capability of renal tubule fatty acid uptake from apical and basolateral membrane in physiology and disease. bioRxiv 2022, doi: https://doi.org/10.1101/2022.07.04.498762. (corresponding author)2022

• 慢性腎臓病における骨・血管連関の分子メカニズムの解明と心血管リスク予測への応用
• 心臓におけるグルコース代謝亢進は重症敗血症の心機能と生命予後を改善する
• 再生血管リモデリング異常のmicroRNA診断および治療手段の確立
• 血管平滑筋細胞の脂肪酸組成と分化転換：糖尿病性動脈硬化の新規メカニズムの解明

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