Ritsumeikan University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 教授

Research keywordsケミカルバイオロジー・エピジェネティクス・ヒストン・構造生物学・創薬

Research fieldsMolecular biology・Structural biochemistry・薬系衛生、生物化学

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• Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics. │ Communications Biology │ 9 (1),4962026
• Discovery of potent substrate-type lysine methyltransferase G9a inhibitors for the treatment of sickle cell disease. │ European Journal of Medicinal Chemistry │ 293,1177212025
• Temperature vaulting: A method for screening of slow- and tight-binding inhibitors that selectively target kinases in their non-native state. │ European Journal of Medicinal Chemistry │ 295,1177892025
• Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture. │ Science Advances │ 11 (47),eadx92822025

• リシンアセチル化による後成遺伝情報の発現と継承の仕組みを理解する │ 基盤研究(B)2024
• LSD阻害剤の創製：LSD1阻害剤の創薬展開およびLSD2機能解明の基盤構築 │ 基盤研究(C)2021
• エピゲノムの修飾密度と分子内相互作用による転写バースト形成の再構成的理解 │ 学術変革領域研究(A)2021
• 人工細胞膜に封入した後成修飾クロマチン繊維の細胞内導入と遺伝子発現の定量的理解 │ 挑戦的研究(萌芽)2020

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