Ritsumeikan University · Faculty of Life Sciences / Graduate School of Life Sciences · 教授

Research keywordsmyeloid-derived suppressor cells・tumor immunology・CCR2 regulation・oncolytic adenovirus・extracellular vesicle therapy・tumor immune escape

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• High potassium enhances the immunosuppressive function of myeloid-derived suppressor cells via Kir4.1-dependent metabolic reprogramming and promotes tumor immune escape. │ International journal of cancer │2025
• [Regulation of myeloid-derived suppressor cells by glutamate]. │ Nihon yakurigaku zasshi. Folia pharmacologica Japonica │ 160 (3),158-162頁2025
• HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells │ Cancer Immunology, Immunotherapy │ 74 (3)2025
• Oncolytic adenovirus serotype 35 mediated tumor growth suppression via efficient activation of antitumor immunity. │ Journal for immunotherapy of cancer │ 13 (7)2025

• 血管を経由する新発想での臓器の脱線維化技術の開発 │ 挑戦的研究(萌芽)2022
• 次世代がん免疫療法に資するパルミチン酸代謝による骨髄由来免疫抑制細胞の制御 │ 基盤研究(B)2022
• 腫瘍溶解性ウイルスによる免疫細胞の腫瘍内浸潤促進機構の解明と更なる促進法の開発 │ 基盤研究(B)2021
• 脂肪酸代謝から解き明かす骨髄由来免疫抑制細胞の制御メカニズムとがん治療への応用2019

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