University of the Ryukyus · Faculty of Medicine

Research keywordsリボソーム・翻訳制御・小胞体ストレス応答・高速原子間力顕微鏡・相分離生物学・mRNAワクチン

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• Metabolic RNA Labeling and Translating Ribosome Affinity Purification for Measurement of Nascent RNA Translation2024 · Hirotatsu Imai, Akio Yamashita
• Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types2024 · Kosuke Tsukamoto, Akio Yamashita, Masatoshi Maeki, Manabu Tokeshi, Hirotatsu Imai, Akira Fukao, Toshinobu Fujiwara, Koji Okudera, Nobuhisa Mizuki, Kenji Okuda, Masaru Shimada
• Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023 · Hirotatsu Imai, Daisuke Utsumi, Hidetsugu Torihara, Kenzo Takahashi, Hidehito Kuroyanagi, Akio Yamashita
• The flexible N-terminal motif of uL11 unique to eukaryotic ribosomes interacts with P-complex and facilitates protein translation2022 · Lei Yang, Ka-Ming Lee, Conny Wing-Heng Yu, Hirotatsu Imai, Andrew Kwok-Ho Choi, David K Banfield, Kosuke Ito, Toshio Uchiumi, Kam-Bo Wong

• 統合的ストレス応答がリボソームを不活化する分子機構の解明2024 · 若手研究
• リボソームストークをハブとする翻訳関連因子プールの機能動態解明2021 · 若手研究
• 高速原子間力顕微鏡で解き明かすリボソームの機能ダイナミクス2020 · 特別研究員奨励費
• 翻訳伸長段階におけるリボソームストークタンパク質複合体の分子動態解析2016 · 特別研究員奨励費

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