University of the Ryukyus · Faculty of Medicine · 講師

Research keywordsthoracic oncology・pleural mesothelioma・Pneumocystis jirovecii diagnosis・lung cancer drivers・respiratory viral epidemiology・digital PCR diagnostics

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• Carcinoma of unknown primary with a lung cancer profile in mediastinal and/or hilar lymph nodes: EGFR-mutant cases and a literature review of actionable drivers.2026 · Tome R, Furugen M, Chinen S, Arakaki W, Miyagi K, Shuri Y, Kawakami F, Wada N, Yamamoto K
• Pemetrexed plus platinum as second-line treatment for patients with pleural mesothelioma treated with nivolumab plus ipilimumab.2025 · Ono S, Taniguchi H, Kuroda K, Hashimoto T, Okada A, Goto Y, Kitai H, Nakamura Y, Ogusu S, Hase T, Ota T, Ebi N, Furugen M, Harada T, Kinoshita Y, Mizoguchi T, Nakatomi K, Soejima Y, Yamada T, Takemoto S, Mukae H
• Evaluation of Diagnostic Performance and Microbiological Efficacy of Pneumocystis Jirovecii Pneumonia by Detection of P. Jirovecii DNA in Blood Samples Using Digital PCR2025 · Ikemiyagi, N; Ideguchi, S; Arakaki, W; Nabeya, D; Nakamura, H; Kinjo, T; Furugen, M; Miyagi, K; Yamamoto, K
• Unseasonal respiratory syncytial virus epidemics during the COVID-19 pandemic: Relationship between climatic factors and epidemic strain switching.2020 · OBJECTIVES: The coronavirus disease (COVID-19) pandemic affected respiratory syncytial virus (RSV) epidemic patterns. However, effects of climatic and virological factors on RSV epidemics remain poorly understood. We investigated the incidence of RSV infection in Okinawa, Japan; Taiwan, China; and Florida, USA before and after the COVID-19 pandemic, focusing on the effects of population mobility and climate. METHODS: We investigated correlations between RSV incidence, human mobility, and climate, pre- and post-pandemic. The second variable region of RSV G proteins was analysed phylogenetically using viral genomes isolated from patients in Okinawa with acute respiratory-tract infections. RESULTS: Annual RSV epidemics in Okinawa were not correlated with human mobility post-pandemic. The temperature and humidity zones at the RSV epidemic onset differed between pre- and post-pandemic periods; the respective standard deviations decreased. Genetic analysis of RSV strains from 2020 to 2022 revealed a cluster with low genetic diversity, markedly different from pre-2019 or 2023 prevalent strains. CONCLUSIONS: Reduced human migration led to an RSV epidemic caused by an indigenous endemic strain, demonstrating the natural relationship between the epidemic and climatic factors. These findings could help develop effective prediction and control programs for RSV epidemics and inform the development of an effective vaccine program.

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