University of the Ryukyus · Faculty of Medicine

Research keywords認知機能障害、神経心理学、認知症、気分障害、概日リズム障害・Cerebellum・Neuroscience・Hippocampal・formation・Hippocampus・Cognition・Episodic

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• Cerebellar Contribution to Pattern Separation of Human Hippocampal Memory Circuits.2016 · Shiroma A, Nishimura M, Nagamine H, Miyagi T, Hokama Y, Watanabe T, Murayama S, Tsutsui M, Tominaga D, Ishiuchi S
• Cerebellar contribution to pattern separation of human hippocampal memory circuits2016 · The cerebellum is a crucial structure for cognitive function as well as motor control. Benign brain tumors such as schwannomas, meningiomas, and epidermoids tend to occur in the cerebellopontine angle cisterns and may cause compression of the posterior lateral cerebellum near the superior posterior fissure, where the eloquent area for cognitive function was recently identified. The present study examined cognitive impairment in patients with benign cerebellar tumors before and after surgical intervention in order to clarify the functional implications of this region in humans. Patients with cerebellar tumors showed deficits in psychomotor speed and working memory compared with healthy controls. Moreover, these impairments were more pronounced in patients with right cerebellar tumors. Functional magnetic resonance imaging during performance of a lure task also demonstrated that cerebellar tumors affected pattern separation or the ability to distinguish similar experiences of episodic memory or events with discrete, non-overlapping representations, which is one of the important cognitive functions related to the hippocampus. The present findings indicate that compression of the human posterior lateral cerebellum affects hippocampal memory function. （管理者追加）リポジトリ登録情報を移行しました。確認のうえ、加除修正をしてください。
• Age-related cognitive decline is accelerated in alcohol use disorder.
• Delayed sleep-wake rhythm is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with major depressive disorder.

• 小脳腫瘍患者における安静時脳内ネットワークの変化によって生じる認知機能障害の解明2001 · 若手研究(B)
• 脳損傷者の認知機能評価と神経心理学的コンサルテーションの明確化
• 安静時機能的MRIとの対応による認知症の包括的認知機能評価システムの構築
• 認知・概日リズム障害に着目した双極性障害の機能的リカバリー改善プログラムの開発

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