University of the Ryukyus · Faculty of Medicine · 助教

Research keywords悪性リンパ腫・成人T細胞白血病/リンパ腫・T細胞リンパ腫

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• Integrated genetic analyses identified T-cell neoplasms other than adult T-cell leukemia/lymphoma in HTLV-1 carriers2026 · Yu Naito, Takahiko Yasuda, Shugo Sakihama, Masayuki Aiba, Kazuho Morichika, Kana Miyazaki, Hiroshi Imai, Ayako Masaki , Takuji Tsuyuki, Satoko Shimada, Makoto Yoshimitsu, Hajime Aoyama, Norihiro Nakada, Takashi Miyagi, Tomoko Tamaki, Bo-Jung Chen, Chang-Tsu Yuan, Takuya Fukushima, Shih-Sung Chuang, Kennosuke Karube
• 扁平上皮分化を伴い，多彩な細胞像を示した甲状腺未分化癌の 1 例2025 · <p><b>背景</b>：甲状腺未分化癌は悪性度の高いまれな疾患である．今回われわれは，甲状腺穿刺吸引細胞診で扁平上皮成分を含む多彩な細胞像を示した甲状腺未分化癌の一例を経験した．</p><p><b>症例</b>：60 歳代，女性．頸部腫瘤を触知，急速増大を認め当院受診．頸部 CT・エコー検査で甲状腺右葉腫瘤と右頸部リンパ節腫大を認め悪性が疑われた．甲状腺細胞診で角化異型細胞が散見され扁平上皮癌が疑われた．組織所見では角化細胞を含む未分化癌と乳頭癌成分が確認され，扁平上皮分化を伴う未分化癌と診断された．細胞所見の再検討で乳頭癌成分や多彩な多核巨細胞，高度異型細胞集塊内への好中球浸潤像が確認された．</p><p><b>結論</b>：甲状腺穿刺吸引細胞診で角化異型細胞を認めた場合は，扁平上皮分化を伴う未分化癌，乳頭癌の扁平上皮化生，甲状腺内胸腺癌，好酸球増多を伴う硬化性粘表皮癌，びまん性硬化型乳頭癌などを念頭に鏡検する必要がある．背景に壊死と炎症細胞を認め，多様な形態を示す大型異型細胞や核の分裂像がみられた際には，扁平上皮分化を伴う未分化癌が推定される．</p>
• Recent progress in pathological understanding of adult T-cell leukemia/ lymphoma in the new classification era2025 · Karube, K; Sakihama, S; Takatori, M; Morichika, K; Tamaki, T; Wada, N; Fukushima, T
• 甲状腺乳頭癌に併発した気管原発粘表皮癌の一例2024 · <p>Primary tracheal carcinoma is a rare malignant tumor; among all malignant tumors, it is reported to occur account for 0.04% of malignancies in Japan and 0.1% in Europe and the United States, with squamous cell carcinoma, accounting for 45%, and adenoid cystic carcinoma, accounting for 41%. We report the case of a 79-year-old woman with papillary thyroid carcinoma, cT4aN0M0 (right recurrent), with laryngeal nerve and tracheal wall invasion, The patient underwent total thyroidectomy, right recurrent laryngeal nerve resection, and tracheal fenestration. On the 16th postoperative day, when attempting to remove the cannula, dyspnea developed, and the bilateral vocal cords were observed. The patient was diagnosed with paralysis. This did not improve despite follow-up. The patient was referred to our hospital for glottis surgery. Preoperative computed tomography (CT) images showed a mass protruding from the left wall of the trachea into the lumen, and pretracheal lymphadenopathy, suggesting intratracheal recurrence of papillary thyroid carcinoma and cervical lymph node metastasis. Therefore, glottis surgery was temporarily suspended and tumor resection (tumor resection including combined resection of the trachea and reconstruction of the tracheal wall using a DP flap) was planned and the operation was performed. A pathological examination revealed papillary carcinoma lymph node metastasis in the pretracheal lymph nodes, but the tumor tissue in the trachea was found to be low-grade mucoepidermoid. carcinoma, not papillary carcinoma. In the present case an intratracheal lesion after surgery for papillary thyroid carcinoma was identified as primary mucoepidermoid carcinoma of the trachea.</p>

• タンパク発現を軸としたT細胞リンパ腫の臨床病理・遺伝子的検討2023 · T細胞リンパ腫(TCL)は、多くのタイプに分類され、予後が大きく異なる。近年、腫瘍細胞が発現するタンパクをターゲットとした抗体療法や分子標的薬が開発され、治療が有効かどうかを反映した正確なタイプ分類が必要となっている。 本研究では、成人T細胞白血病/リンパ腫(ATLL)における免疫組織化学染色(IHC)を用いたタンパク発現解析 [Tamaki T, et al. Mod Pathol, 2023] を他のTCLに応用することで、(1)ATLLを他のTCLと正確に区別すること、(2)新しい治療の標的となるATLLのタンパク発現の特徴を見つけることを目的とし、IHCと遺伝子変異解析を行い検討する。

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