University of the Ryukyus · Faculty of Agriculture · 教授

Research keywordsmarine natural products・sesquiterpenes・diterpenoids・antifouling compounds・antimalarial metabolites・marine chemical ecology

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• Cadinane-type sesquiterpene from Japanese soft coral of the genus Xenia and its biological activities2026 · Shioiri, M; Nakagawa, R; Suzuki, R; Ichikawa, K; Nimura, K; Fukada, R; Tani, K; Ishii, T; Kumagai, M; Kamada, T
• Elucidation of a New Snyderane-Type Sesquiterpene from Okinawan Sea Hare Aplysia argus and Identification of Their Feeding Targets.2026 · Fukada R, Nakagawa R, Yokoshima K, Inafuku M, Kumagai M, Kamada T, Ishii T
• Skeletal Diversity of Diterpenoids Isolated from the Soft Coral Sclerophytum heterospiculatum in Kikai Island2026 · Tani, K; Tsuruta, T; Yoshino, Y; Fukushige, A; Doe, M; Miyake, H; Morimoto, Y; Hashimoto, M; Ukiya, M; Marumoto, S; Ishii, T; Nishikawa, K
• Ufisonitriles A and B, Antimalarial Isonitriles with Mitochondrial Function Inhibitory Activity Produced by Amycolatopsis sp. OK19-00092025 · Two novel antimalarials, named ufisonitriles A (1) and B (2), were isolated by bioassay-guided fractionation on mitochondrial function inhibitory activity using multidrug-sensitive budding yeast from the cultured broth of the Okinawan rare actinomycete Amycolatopsis sp. OK19-0009 strain. Their structures were comprehensively elucidated using HR-ESI-MS and 1D/2D NMR analyses and the modified Mosher's method. Structurally, 1 and 2 possess a novel skeleton with an isocyano group. In vitro antimalarial evaluation against Plasmodium falciparum strains revealed that 1 and 2 exhibited moderate activity with IC50 values ranging from 28.6 to 1.12 μM. Furthermore, 1 and 2 reduced the malaria parasites by approximately 45% in vivo on intraperitoneal administration (30 mg/kg/day for 4 days) with no observed toxicity. We also provide a plausible biosynthesis pathway based on the genome sequence analysis.

• 沖縄産軟体サンゴホロビオントを探索源とした「環境調和型の新規魚類疾病薬剤」の創出2022 · 基盤研究(C)
• オーキシン主要生合成酵素YUCCAに特異的に作用する発展型阻害の追求2014 · 独自に保有する化合物・抽出物ライブラリー約200種より、YUCCA酵素阻害試験（in vitro）およびシロイヌナズナ初期生育試験（in vivo）を用いてスクリーニングした結果、紅藻ソゾやアメフラシ類の抽出物ならびにTRPチャネル阻害剤の2-APBに強い阻害効果が認められた。上記の抽出物より、既知のYUCCA阻害物質とは異なる化学構造を有する天然物として、laurane型の含ハロゲンセスキテルペン3種を取得することに成功した。その内、laurinterolと2-APBは、in vivo試験において既知の阻害物質よりも強い阻害効果を示すことが確認できた。

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