Saitama Medical University · Faculty of Medicine / Graduate School of Medicine · 教授

Research keywordsCancer Pharmacology・Natural Products Chemistry・Breast Cancer・Glioblastoma・Pancreatic Cancer・Apoptosis Induction・Histone Deacetylase Inhibitors

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• Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
• Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase.
• Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme.
• Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.

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