Saitama Medical University · Faculty of Medicine / Graduate School of Medicine

Research keywordstype 1 diabetes・NOD mice・regulatory T cells・TNFR2 agonists・CXCR3 signaling・CXCL10 vaccination・autoimmune hyperglycemia

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• Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling.
• Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese.
• Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs.
• A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse.

• I型糖尿病における膵島抗原GADのT細胞エピトープの検討
• 1型糖尿病発症におけるケモカインレセプターの同定とその発症制御

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