Saitama Medical University · Faculty of Medicine / Graduate School of Medicine · 助教

Research keywordsCD26 targeted therapy・malignant mesothelioma・multiple myeloma・osteoclast development・monoclonal antibodies・cell cycle arrest

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• Blockade of CD26 Signaling Inhibits Human Osteoclast Development
• CD26 is a potential therapeutic target by humanized monoclonal antibody for the treatment of multiple myeloma.
• Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with anti-tumor effect.
• Establishment of a novel childhood acute myeloid leukemia cell line, KOPM-88, containing partial tandem duplication of the MLL gene and an in vivo model for childhood acute myeloid leukemia using NOD/SCID mice.

• 核内へ移行するscFVモノクローナル抗体の開発研究
• 小児急性骨髄性白血病におけるMLL遺伝子縦列部分重複の機能解析と分子標的治療
• 核内移行するヒト化抗CD26抗体によるスーパーエンハンサー標的抗がん療法の開発
• 小児急性骨髄性白血病の動物モデルを用いたDIC発症の分子機構の解析

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