Saitama Medical University · Faculty of Medicine / Graduate School of Medicine · 准教授

Research keywordsembryonic stem cells・neural stem cell viability・Sox2 function・nucleostemin・Nanog Esrrb・PI3K Myc signaling・extraembryonic endoderm differentiation・fibronectin enhancer

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• Putative stemness gene Jam-B is not required for maintenance of stem cell state in embryonic, neural, and hematopoietic stem cells
• The Sox2 regulatory regions display their activities in two distinct types of multipotent stem cells.
• Oct-3/4 maintains the proliferative embrynic stem cell state via specific binding to a variant octamer sequence in the regulatory region of the UTF1 locus.
• Sirt1, p53, and p38(MAPK) are crucial regulators of detrimental phenotypes of embryonic stem cells with Max expression ablation.

• 2013/04～ 転写補助因子UTF1ノックアウトオスマウスの不妊症メカニズムの解明 国内共同研究 （キーワード：発生生物学）2013 · 研究課題・受託研究・科研費
• 2010/01～ 胚性幹細胞における時計遺伝子のクロマチン状態の解析 国内共同研究2010 · 研究課題・受託研究・科研費
• 胚性幹細胞における時計遺伝子のクロマチン状態の解析
• ES細胞の腫瘍性を規定する遺伝子の異所性発現による腫瘍化の分子機構解明

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