Setsunan University · Faculty of Pharmaceutical Sciences · 講師

Research keywordsorganofluorine synthesis・C-F bond cleavage・fluorinated isoxazolines・electrophilic benzylation・MATE transporter inhibitors・CYP3A4 inhibition・machine learning in drug discovery・integrin antagonists・beta-lactam synthesis

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• Simple synthesis of multi-halogenated alkenes from 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane)
• Mild Amide-Cleavage Reaction Mediated by Electrophilic Benzylation
• LCP: Simple Representation of Docking Poses for Machine Learning: A Case Study on Xanthine Oxidase Inhibitors
• Yohei Yasuno, Atsushi Tarui, Shoki Hoshikawa, Yukiko Karuo, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote論文

• 多剤耐性菌のMATE型多剤排出ポンプを選択的に阻害するリード化合物の創出
• 小分子な蛍光性化合物の開発と歯周病菌の蛍光プローブ創製
• 従来法では不可能なアルコール中で求核的フッ素化できる環境調和型フッ素化法の創出
• 従来法では不可能なアルコール中で求核的フッ素化できる環境調和型フッ素化法の創出

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