Setsunan University · Faculty of Pharmaceutical Sciences · 准教授

Research keywordschronic social defeat stress・anxiety-like behavior・serotonin transporter・prefrontal serotonergic system・2'-fucosyllactose・gut microbiota・amygdala hyperactivity・folate deficiency・neuronal DNA hypomethylation・metabotropic glutamate receptors

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• Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice2024
• 2′-Fucosyllactose Alleviates Early Weaning-Induced Anxiety-Like Behavior, Amygdala Hyperactivity, and Gut Microbiota Changes2023
• Low folate induces abnormal neuronal maturation and DNA hypomethylation of neuronal differentiation-related genes in cultured mouse neural stem and progenitor cells2021 · Heliyon
• Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice

• モノアミン神経系とエピジェネティクスに着目した漢方薬の抗うつ作用メカニズム解析
• オンジ由来GDNF発現誘導化合物の抗うつ作用の解析
• 発育期における神経精神機能の発達異常に対する漢方治療の基礎的研究
• 統合失調症における代謝型グルタミン酸２／３受容体の創薬的意義に関する研究

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