Shimane University · University Hospital

Research keywordscancer metabolism・diabetes and cancer・breast cancer metastasis・CXCL12 CXCR4 signaling・epithelial-mesenchymal transition・antidiabetic drugs

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• The PKM2 activator TEPP‐46 suppresses cellular senescence in hydrogen peroxide‐induced proximal tubular cells and kidney fibrosis in CD‐1db/dbmice
• NAD+ deficiency plays essential roles in the hyperuricemia of stroke-prone spontaneously hypertensive rat via xanthine dehydrogenase to xanthine oxidase conversion.
• Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis.
• Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon.

• サルコペニア合併糖尿病性腎臓病における負のスパイラルを標的とした治療戦略の開発
• COMT遺伝素因とMg欠乏が惹起する健康被害の分子機構解明と新規治療戦略の開発
• DPP-4阻害薬によるオートファジー誘導を介した乳癌進展機構の解明

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