Shimane University · University Hospital · 教授

Research keywordsinterleukin-18・colitis models・monoclonal antibodies・Schlafen proteins・DNA damage sensitivity

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• Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier Function2023
• The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 13.2023
• Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases.2022
• Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-182019

• 家族性地中海熱の病態における免疫老化の意義を明らかにする研究2022
• パイリンインフラマソーム活性化メカニズムの解明とその制御法の開発2020
• IL-18阻害抗体をもちいた新規膵がん治療法の開発2020
• 家族性地中海熱の「早期診断」と「精密医療の実現」に向けたバイオマーカーの開発2019

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