Shimane University · Faculty of Bioresource Sciences · 教授

Research keywords腎臓・腸管・血管・転写因子・近位尿細管細胞・遺伝子発現・脱リン酸化・肝臓・内皮細胞・動脈硬化

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• Increased Prorenin Expression in the Kidneys May Be Involved in the Abnormal Renal Function Caused by Prolonged Environmental Exposure to Microcystin-LR.
• Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.
• Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells.
• Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation

• 腸内細菌代謝産物に焦点を当てた高食肉摂取による健康増進と病態発症の分岐点の解明
• HIF-1α/β複合体形成阻害分子による腎性貧血でのEPO産生抑制機構の解明
• 亜鉛欠乏によるEpo産生抑制メカニズムの解明
• コール酸を用いた新たな脂肪肝誘発モデル動物の作製

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