Shimane University · Faculty of Medicine · 教授

Research keywordshematopoietic stem cells・myelodysplastic syndrome・hepatocellular carcinoma・cancer stem cells・epigenetic regulation・Bmi1 signaling・Tet2 Ezh2

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• [Structure and function of MYST family histone acetyltransferases].
• Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.
• Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promoter of the rat aldolase B gene.
• Role of SoxB1 transcription factors in development.

• 生殖系幹細胞の自己複製制御機構の解明
• ヒストンアセチル化酵素HBO1の造血における役割
• RNAiスクリーニングによるT細胞性急性リンパ性白血病の創薬標的遺伝子の同定
• 転写共役因子TIFbの造血幹細胞における役割

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