Shimane University · Faculty of Medicine

Research keywordsmajor depressive disorder・mood disorders・neurotrophic factors・DNA methyltransferases・histone deacetylases・sirtuins・epigenetics・antidepressant mechanisms

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• State-dependent changes in the expression of DNA methyltransferases in mood disorder patients.
• Identification of commonly altered genes between in major depressive disorder and a mouse model of depression.
• Prompt improvement of difficulty with sleep initiation and waking up in the morning and daytime somnolence by combination therapy of suvorexant and ramelteon in delayed sleep-wake phase disorder: a case series of three patients.
• Normalizing hyperactivity of the Gunn rat with bilirubin-induced neurological disorders via ketanserin.

• ヒストン脱アセチル化酵素を標的とした新規抗うつ薬創薬研究
• 電気けいれん療法の抗神経炎症作用の包括的解明
• 双極性障害における軸索構造ネットワークの分子生物学的病態解明
• 抑うつに関与する脳腸神経ペプチドが気分障害患者の脳基盤異常に与える影響

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