Shimane University · Faculty of Medicine

Research keywordsstroke-prone spontaneously hypertensive rat・salt-sensitive kidney injury・Stim1 mutation・astrocyte calcium signaling・RVLM blood pressure regulation・apolipoprotein E depletion・arginine vasopressin・hypertensive cerebrovascular disease

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• Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat.
• A 3-Mbp fragment on rat chromosome 1 affects susceptibility both to stroke and kidney injury under salt loading in the stroke-prone spontaneously hypertensive rat: a genetic approach using multiple congenic strains.
• Evaluation of Pathological Association between Stroke-Related QTL and Salt-Induced Renal Injury in Stroke-Prone Spontaneously Hypertensive Rat.
• Dual inhibition of NADPH oxidases and xanthine oxidase potently prevents salt-induced stroke in stroke-prone spontaneously hypertensive rats.

• 高血圧責任遺伝子同定への新規アプローチ：ストレス応答遺伝子と高血圧をつなぐ
• 遺伝的脳卒中モデルラットの血液脳関門は脆弱かーインビトロ再構築技術を用いた検討
• 高血圧性疾患の予防・治療法開発への応用を目指した、免疫遺伝学的分子基盤の探索
• 高血圧責任遺伝子同定への新規アプローチ：ストレス応答遺伝子と高血圧をつなぐ

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