Shinshu University · Department of Medicine / Faculty of Medicine · 准教授

Research keywordsheme proteins・heme signaling・oxygen activation・metalloprotein biochemistry・ephrin cleavage・pyroptotic death

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• Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci
• C1D is not directly involved in the repair of UV-damaged DNA but protects cells from oxidative stress by regulating gene expressions in human cell lines.
• Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner.
• Non-vesicular extracellular RNA: A potential drug target to intervene cell-cell communication.

• ヘムオキシゲナーゼの酵素反応を原子スケールで追跡する
• 転移性肺がんにおける酸化ＬＤＬ受容体とＴＬＲ４シグナリングのクロストーク
• 血清アミロイドA3の分子機構と新規細胞内情報伝達タンパク質mTOC
• 細胞外RNA受容体ZC3H12Dの細胞内機能解析

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