Shinshu University · Department of Medicine / Faculty of Medicine · 准教授

Research keywordscalcium signaling・store-operated calcium entry・Orai1 isoforms・TRPC channels・depolarization-induced calcium release・skeletal muscle disease・arteriogenesis・polycystin-2

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• Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation
• A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+ Entry via Association with TRPC3 and TRPC7
• Activation and regulation of store-operated calcium entry
• The role of canonical transient receptor potential 7 in B-cell receptor-activated channels

• 成体における新生血管の成熟を決定する分子機構の解明と創薬応用
• 動脈硬化におけるCaV1.2のC末端リン酸化の重要性解明と創薬展開
• 新規再構成系を用いた骨格筋脱分極誘発性Ca2+遊離機構の解明
• 新規リアノジン受容体作用薬を利用したサブタイプ特異的チャネル制御の分子機構

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